Preclinical sleep research remains constrained by labor intensive, manual vigilance state classification and inter rater variability, limiting throughput and reproducibility. This study presents an automated framework developed by Team Neural Prognosticators to classify electroencephalogram (EEG) recordings of small rodents into three critical vigilance states paradoxical sleep (REM), slow wave sleep (SWS), and wakefulness. The system integrates advanced signal processing with machine learning, leveraging engineered features from both time and frequency domains, including spectral power across canonical EEG bands (delta to gamma), temporal dynamics via Maximum-Minimum Distance, and cross-frequency coupling metrics. These features capture distinct neurophysiological signatures such as high frequency desynchronization during wakefulness, delta oscillations in SWS, and REM specific bursts. Validated during the 2024 Big Data Health Science Case Competition (University of South Carolina Big Data Health Science Center, 2024), our XGBoost model achieved 91.5% overall accuracy, 86.8% precision, 81.2% recall, and an F1 score of 83.5%, outperforming all baseline methods. Our approach represents a critical advancement in automated sleep state classification and a valuable tool for accelerating discoveries in sleep science and the development of targeted interventions for chronic sleep disorders. As a publicly available code (BDHSC) resource is set to contribute significantly to advancements.

Driving under drowsy conditions significantly escalates the risk of vehicular accidents. Although recent efforts have focused on using electroencephalography to detect drowsiness, helping prevent accidents caused by driving in such states, seamless human-machine interaction in driving scenarios requires a more versatile EEG-based system. This system should be capable of understanding a driver's intention while demonstrating resilience to artifacts induced by sudden movements. This paper pioneers a novel research direction in BCI-assisted driving, studying the neural patterns related to driving intentions and presenting a novel method for driving intention prediction. In particular, our preliminary analysis of the EEG signal using independent component analysis suggests a close relation between the intention of driving maneuvers and the neural activities in central-frontal and parietal areas. Power spectral density analysis at a group level also reveals a notable distinction among various driving intentions in the frequency domain. To exploit these brain dynamics, we propose a novel Masked EEG Modeling framework for predicting human driving intentions, including the intention for left turning, right turning, and straight proceeding. Extensive experiments, encompassing comprehensive quantitative and qualitative assessments on public dataset, demonstrate the proposed method is proficient in predicting driving intentions across various vigilance states. Specifically, our model attains an accuracy of 85.19% when predicting driving intentions for drowsy subjects, which shows its promising potential for mitigating traffic accidents related to drowsy driving. Notably, our method maintains over 75% accuracy when more than half of the channels are missing or corrupted, underscoring its adaptability in real-life driving.